Recent Advances Towards Rational Antibacterial Discovery: Addressing Permeation and Efflux

Avila, Q.P.; Zgurskaya, H.I.; Duerfeldt, A.S.

Accepted for publication in 2017 ACS Med. Chem. Reviews

Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P

Lavey, N.P.; Coker, J.A.; Ruben, E.A.; Duerfeldt, A.S.

J. Nat. Prod., 2016, 79, 1193.

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Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

Crowley, V.M.; Khandelwal, A.; Mishra, S.; Stothert, A.R.; Huard, D.J.E.; Zhao, J.; Muth, A.; Duerfeldt, A.S.; Kizziah, J.L.; Lieberman, R.L.; Dickey, C.A.; Blagg, B.S.J.

J. Med. Chem., 2016, 59, 3471.

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Grp94 Delivers gamma-aminobutyric Acid Type A (GABA) Receptors to Hrd1-Mediated Endoplasmic Reticulum-Associated Degradation

Di, X.J.; Wang, Y.J.; Han, D.Y.; Fu, Y.L.; Duerfeldt, A.S.; Blagg, B.S.J.; Mu, T.W.

J. Biol. Chem., 2016, 291, 9526.

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Cycloadditions of Noncomplementary Substituted 1,2,3-Triazines

Anderson, E.A.; Duerfeldt, A.S.; Zhu, K.; Glinkerman, C.M.; Boger, D.L.

Org. Lett., 2014, 16, 5084–5087.

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Stereoselective Syntheses of (–)-Pyrimidoblamic Acid and P-3A

Duerfeldt, A.S.; Boger, D.L.

J. Am. Chem. Soc., 2014, 136, 2119−2125.

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Fundamental Relationship Between Hydrophobic Properties and Biological Activity for the Duocarmycin Class of DNA Alkylating Antitumor Drugs: Hydrophobic Binding-Driven-Bonding

Wolfe, A.L., Duncan, K.K., Lajiness, J.P., Zhu, K., Duerfeldt, A.S., Boger, D.L.

J. Med. Chem., 2013, 56, 6845–6857.

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Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism

Suntharalingam, A.; Abisambra, J.F.; O’Leary, J.C.; Koren III, J.; Zhang. B.; Kuk Joe, M.; Blair, L.J.; Hill, S.E.; Jinwal, U.K.; Cockman, M.; Duerfeldt, A.S.; Tomarev, S.; Blagg, B.S.J.; Lieberman, R.L.; Dickey, C.A.

J. Biol. Chem., 2012, 287, 40661–40669.

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Development of a Grp94 Inhibitor

Duerfeldt, A.S.; Peterson, L.B.; Maynard, J.C.; Ng, C.L.; Eletto, D.; Ostrovsky, O.; Shinogle, H.E.; Moore, D.S.; Argon, Y.; Nicchitta, C.V.; Blagg, B.S.J.

J. Am. Chem. Soc., 2012, 134, 9796–9804.

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Synthesis and Biological Evalu